Bonn, once a city that played a significant role in late 20th century world affairs, has not featured in news reports as frequently in recent years having been shorn of the German parliament in 1990. The city is now one of three German cities seeking to host the European Medicines Agency. The city that hosts the Federal Institute for Drugs & Medical Devices is definitely ‘one to watch’. Furthermore, the fact that Bonn also hosts the European Association for the Study of Diabetes and the European Society of Oncology Research will also count in its favour. Both of the organisations referenced have close ties with the EMA. The recent KPMG report placed Bonn ahead of cities such as Dublin, Brussels, Barcelona, Madrid, Rome and others in the competition to host the European Medicines Agency. While the city might have slipped from the minds of many since its days as the West German capital, it still hosts a number of government departments and it plays an important part in German governmental infrastructure. As one would expect from a major world economy, Germany is a world leader in life sciences. Bonn and its near neighbour cities of Aachen, Cologne and Leverkusen host a large number of globally known companies such as: North Rhine Westphalia (NRW) region is home, in Leverkusen, to global giant Bayer. The region is regarded by many as Germany’s economic engine. From a scientific perspective, the NRW region offers much to the European Medicines Agency including 6 of Germany’s top 12 largest universities. Let’s look at the strengths, weaknesses, opportunities, and threats faced by Bonn.