The transition from paper-based submissions to the more costly eCTD system has caused many companies to reconsider how they undertake regulatory publishing. Acorn Regulatory was an industry leader in the early adoption of eCTD technology in 2014 and we have worked with hundreds of companies to manage their electronic submissions and to train their staff in eCTD technologies since then. This article looks at the three options open to companies when considering how to manage eCTD publishing & submission within their company.